A wide variety of agricultural uses (>100 different crops) including vegetables, tree fruits, grapes, other fruits, tree nuts, beans, some cereal grains, corn, soybeans, cotton, sugar beets, peanuts, and other crops. Landcape uses include trees and landscape plantings. Other uses include nursery uses and non-crop uses.
Carlson et al. (2001) notes methoxyfenozide to be "modestly root-systemic (particularly in rice and other monocots) but not significantly leaf-systemic." Nonetheless, this paper presents study data showing prolonged efficacy on leaf-feeding Lepidoptera after soil drenches. Chemicals in the diacylhydrazine class of insecticides mimic the action of the molting hormone of Lepidopteran (moths, butterflies) larvae. Upon ingestion, Lepidopteran larvae undergo a lethal premature molt. EPA's 2018 registration decision noted 10 bee kills reported since 2011 (6-7 involved at least one additional pesticide in addition to methoxyfenozide).
U.S. Environmental Protection Agency (EPA). 2015. Registration Review: Preliminary Environmental Fate and Ecological Risk Assessment Endangered Species Effects Determination for Methoxyfenozide. 72 pp.
Carlson, G., T. Dhadialla, R. Hunter, R. Jansson, C. Jany, Z. Lidert, and R. Slawecki. 2001. The Chemical and Biological Properties of Methoxyfenozide, a New Insecticidal Ecdysteroid Agonist. Pest Management Science 57(2):115–119.
U.S. Environmental Protection Agency (EPA). 2015. Registration Review: Preliminary Environmental Fate and Ecological Risk Assessment Endangered Species Effects Determination for Methoxyfenozide. 72 pp.